Organ Attack Review: A Hilariously Twisted Trip Through the Human Body

There are board games that teach strategy. There are board games that foster cooperation. There are board games that simulate farming, trading in the Mediterranean, building civilizations, or surviving zombie apocalypses.

And then there’s Organ Attack, a game that asks a much more important question:

What if you could give your friend a case of Kidney Stones while simultaneously protecting yourself with a pair of healthy lungs?

Welcome to the delightfully disturbed world of Organ Attack.

What Is Organ Attack?

Created by the folks at Awkward Yeti, Organ Attack is a card game inspired by the wildly popular webcomic series featuring personified organs, diseases, and bodily functions. The premise is simple:

Each player starts with a collection of organs.

Your goal?

Destroy everyone else’s organs before they destroy yours.

How do you accomplish this noble medical objective?

By inflicting diseases, injuries, and horrifying bodily ailments upon your opponents while using treatments and immunities to keep yourself alive.

It’s basically Uno if Uno had a dark sense of humor, a basic understanding of anatomy, and absolutely no regard for your long-term health.

First Impressions

The first thing you’ll notice is the artwork.

If you’ve ever seen an Awkward Yeti comic, you’ll immediately recognize the style. The organs are expressive, adorable, and somehow incredibly relatable despite being, well… organs.

The Liver looks perpetually exhausted.

The Brain is stressed.

The Heart is overly emotional.

The Stomach is having a rough day.

Which, if we’re being honest, sounds a lot like most adults.

The artwork carries the game. It gives every card personality and turns what could have been a generic take-that card game into something memorable and genuinely funny.

Even players who don’t normally care about art in board games tend to comment on it.

And when a game can make someone laugh simply by drawing an angry spleen, that’s worth something.

Gameplay: Controlled Chaos

The rules are straightforward enough that you can teach new players in a matter of minutes.

Each player starts with four organs.

On your turn, you’ll draw cards, play diseases on opponents, cure your own ailments, or use special action cards to wreak havoc around the table.

The diseases range from the mildly inconvenient to the alarmingly realistic.

You might inflict:

• Kidney Stones
• Anxiety
• Heart Attack
• Diabetes
• Cancer
• Infection

And a whole host of other conditions that would normally warrant a trip to the doctor rather than enthusiastic laughter.

The game quickly becomes a battlefield of escalating medical catastrophes.

One player develops asthma.

Another suffers organ failure.

Someone else receives a miraculous transplant.

A fourth player is somehow surviving despite appearing to have every condition known to modern medicine.

It’s glorious.

The “Take That” Factor

Let’s address the elephant in the operating room.

Organ Attack is absolutely a “take that” game.

If your gaming group dislikes direct confrontation, targeted attacks, and occasionally being singled out for reasons that can only be described as petty revenge, this may not be the game for you.

Players are constantly attacking one another.

Alliances form.

Grudges emerge.

Temporary truces collapse almost immediately.

The player who looked safe two turns ago suddenly finds themselves suffering from multiple diseases and missing half their organs.

The player who appeared doomed somehow wins.

There’s a beautiful unpredictability to it.

Unlike deeply strategic games where victory is determined through long-term planning, Organ Attack thrives on chaos, timing, and social dynamics.

The best move isn’t always the mathematically optimal one.

Sometimes it’s simply attacking the person who gave you a heart attack three turns earlier.

Justice must be served.

Surprisingly Educational?

I hesitate to call Organ Attack educational.

That feels like the kind of thing a teacher says right before forcing students to watch a documentary.

But it is interesting how often players begin discussing actual medical conditions during gameplay.

I’ve seen conversations emerge around:

• What the spleen actually does
• Why kidney stones are terrifying
• Whether people can survive without certain organs
• Which diseases are genuinely hereditary
• Why everyone suddenly feels concerned about their liver

No one is becoming a doctor after playing this game.

But they might accidentally learn something.

Accessibility and Replayability

One of Organ Attack’s greatest strengths is accessibility.

You don’t need a dedicated gaming group.

You don’t need an engineering degree.

You don’t need to spend forty-five minutes explaining worker placement mechanics.

You can teach this game to casual gamers, family members, coworkers, and people who haven’t played a board game beyond Monopoly.

The humor does a lot of the heavy lifting.

People immediately understand what’s happening because the concept is inherently funny.

Replayability remains strong because player interactions drive the experience.

No two games unfold quite the same way.

Different disease combinations, shifting alliances, and varying levels of table chaos ensure that every session develops its own personality.

The Downsides

No game is perfect.

The biggest criticism is that luck plays a significant role.

Card draws matter.

Sometimes you’ll get exactly what you need.

Sometimes you’ll stare helplessly at your hand while your opponents systematically dismantle your internal organs.

Players seeking deep strategic complexity may find the experience a bit light.

This isn’t Terraforming Mars.

It isn’t Twilight Imperium.

It isn’t attempting to be.

The game prioritizes fun, interaction, and laughter over intricate decision trees.

Additionally, highly competitive players may occasionally feel frustrated when random card draws determine the outcome of a close game.

But frankly, that’s part of the charm.

The game is less about proving who is the smartest player at the table and more about creating memorable stories.

Final Thoughts

Organ Attack understands exactly what it wants to be.

It isn’t trying to reinvent tabletop gaming.

It isn’t trying to become the next great strategic masterpiece.

Instead, it delivers something arguably more valuable:

A fast, funny, easy-to-learn game that gets people laughing.

In an era where many board games seem determined to become increasingly complex, Organ Attack embraces simplicity without sacrificing personality.

Its combination of dark humor, charming artwork, accessible gameplay, and relentless player interaction makes it an easy recommendation for casual gaming groups.

Will it become your group’s most strategically revered game?

Probably not.

Will you remember the time your cousin gave you Anxiety, followed by Kidney Stones, before finishing off your Liver with a Heart Attack card?

Absolutely.

And honestly, that’s what good party games are supposed to do.

Rating: 8.5 / 10

Pros

• Fantastic artwork
• Easy to teach and learn
• Constant player interaction
• Genuinely funny theme
• Great for casual groups

Cons

• Significant luck factor
• Limited strategic depth
• Can feel mean-spirited for players who dislike direct attacks

Bottom Line:
Organ Attack is equal parts anatomy lesson, medical nightmare, and comedy show. It’s the kind of game that creates stories you’ll still be laughing about weeks later—assuming your organs survive the experience.

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